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Author

Alan J. Thomas

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2 papers indexed here

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Open access Oct 2026

Deep phenotyping of white matter tissue composition in dementia with Lewy bodies

White matter signal abnormalities (WMSA) on MRI are common in dementia with Lewy bodies (DLB), and more severe WMSA have been associated with increased neurodegeneration in DLB. However, the underlying mechanisms of WMSA remain unclear. Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD) is a d...

Anna Rennie, M. Němý, A. Badji et al. · 0 citations
Open access Sep 2026

Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study

Here, we conduct a large meta-analysis of DNA methylation across multiple cortical brain regions, in relation to increasing burden of Lewy body pathology. Utilizing a dataset of 1205 samples (832 unique donors), we identify 24 false discovery rate significant differentially methylated loci associated with Lewy body...

Joshua Harvey, J. Imm, Morteza Kouhsar et al. · 0 citations

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