Open access
Aug 2026
A mouse model of autosomal dominant spastic ataxia and myopathy caused by a mutation in Tuba4a
The authors' mice exhibit hallmark features of SPAX11 and CMYO26, but do not show motor neuron degeneration, which makes this model a valuable tool for studying cell-type selective effects of TUBA4A mutations in neurodegeneration and myopathy.
T. Hines, Jonathan R. Funke, S. L. Pratt et al.
· Human Molecular Genetics · 0 citations