Author

Alba Sansa

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Open access Sep 2026

Differentiation protocol and maturation shape the axial identity and synaptic state in human iPSC-derived spinal motor neurons

Human induced pluripotent stem cell (iPSC)-derived motor neurons are widely used for disease modeling. Stem cells can be differentiated into motor neurons by exposure to specific patterning morphogens, which can ultimately determine terminal cellular composition and developmental state. We compared two small molecule w...

Alba Sansa, Vladimir A. Zhemkov, M. Feole et al. · bioRxiv · 0 citations

Open access Jul 2026

Antisense oligonucleotides treatment uncovers differences in the modulation of dysregulated intracellular pathways in Spinal Muscular Atrophy motoneurons.

Spinal Muscular Atrophy (SMA) is a neuromuscular genetic disorder resulting from the mutation or deletion of the Survival Motor Neuron 1 (SMN1) gene and the reduction of the Survival Motor Neuron (SMN) protein. As a result, SMN level in SMA depends on the almost identical copy gene SMN2, which produces a small amount o...

María P. Miralles, Isabel Gimenez-Fernandez, María Beltran et al. · Cell Death and Disease · 0 citations