Open access
Oct 2026
Genetic variants shape single-cell chromatin accessibility and disease risk.
Understanding how genetic variation shapes gene regulation at single-cell resolution is crucial for elucidating complex disease mechanisms1, but has been limited by the lack of large-scale single-cell multi-omics data2-4. Here we present single-cell assay for transposase-accessible chromatin with sequencing of 3.5 mill...
A. Xue, Jia-Nan Fan, Oscar A. Dong et al.
· Nature · 3 citations