Alejandro Melo-Florián

Inflammaging as a systems-level integrator of disease: Biological foundations of chronic low-grade inflammation

This review examines the biological foundations of inflammaging, emphasizing immunosenescence, senescence-associated secretory pathways, mitochondrial dysfunction, inflammasome biology, cytokine network dynamics, and epigenetic regulation, and proposes that inflammaging is best understood as multiscale biological interface failure.