Open access
Sep 2026
eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma
Findings show that multiple resistance-associated programs spanning signaling, cell survival, and metabolism share a dependency on eIF4A-dependent translation and provide a preclinical rationale to test whether adding eIF4A inhibition can prolong responses to MAPK-targeted therapy in melanoma.
Alejandro Schcolnik-Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad et al.
· bioRxiv · 0 citations