Open access
Oct 2026
Gut Microbiota Fuel Aging Induced by Mitochondrial Dysfunction
Francesca Solagna, D. Martínez-Martínez, Norma Gabriela Zavala-Torres et al.
· bioRxiv · 0 citations
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Review
Open access
Sep 2026
Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities
This review discusses the physiological functions and substrate selectivity of CLPXP, the mechanistic basis and clinical development of CLPP inhibitors and activators, and the growing evidence that therapeutic responses depend strongly on tissue identity, metabolic state and the nature of the underlying mitochondrial d...
L. Isermann, Aleksandra Trifunovic
· Journal of Inherited Metabol... · 0 citations