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The HUWE1-HAPSTR1-USP7 complex is established as a key ubiquitin code modifier, providing a molecular rationale for HUWE1 dysregulation in neurodevelopmental disorders and cancer.
The development of scalable iPSC-neuron models enables tauopathy drug discovery and reconstructs progressive Tau seeding, fibrillization and synaptic dysfunction, and establishes a physiologically relevant, scalable platform for therapeutic screening that connects Tau seed uptake, site-specific phosphorylation, fibril...
SynActive-PSD95-FLAG, a genetically encoded probe consisting of FLAG-tagged PSD- 95 endowed with activity-dependent local translation and expression enrichment at potentiating dendritic spines, provides new insight into the molecular substrates of hippocampal learning and a novel tool to study the proteome of potentiat...
This work identifies LMOD1 as a new regulator that might be targeted to improve muscle regeneration in aging and disease and demonstrates that LMOD1 influences SIRT1 localization and the expression of its target genes.
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