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GLP-1 receptor agonists for Alzheimer’s disease: Lessons from trials and translational challenges
Although GLP-1 receptor agonists show strong mechanistic rationale and supportive epidemiological signals for neuroprotection, large randomized trials in symptomatic AD have yielded negative clinical outcomes and do not support the therapeutic use in AD.
Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice
The principles of harmonized reporting for Alzheimer’s disease biomarkers and a structured framework for standardized clinical neurochemistry reports are discussed and a structured framework for standardized clinical neurochemistry reports is proposed.