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Author

Alex Adrian-Hamazaki

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Open access Sep 2026

Chromosomal mutational signatures of DNA damaging agents at single cell resolution

The chromosomal-scale mutational spectrum of small molecules that interact with DNA has been hard to study at scale, as mutational events are distributed in location and occur in parallel in different cells. Here, we present a framework that pairs phylogenetic ancestry reconstruction with mutational signature decomposi...

Mirela Andronescu, Alex Adrian-Hamazaki, Damian Boon Siew Yap et al. · 0 citations
Open access Sep 2026

Gene function prediction from bulk coexpression is bounded by cell-type-level signal

This work shows that gene function is predictable from coexpression substantially because it reflects differences in expression between cell types, and these differences are also intrinsic to the ground truth labels, and indicates that function prediction models trained on bulk coexpression are largely limited to cell-...

Alex Adrian-Hamazaki, P. Pavlidis · 0 citations

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