Alex R. Hopke

Outbreaks of fluconazole-resistant Candida parapsilosis are driven by low-biofilm-producing isolates that emerge under host selection

It is shown that FLCR-Cp isolates responsible for prolonged, multi-country outbreaks consistently exhibit a striking low-biofilm-producing (LBP) phenotype, overturning the assumption that robust biofilm formation drives outbreak persistence and identifying biofilm attenuation as an adaptive tradeoff that promotes immun...