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Open access Oct 2026

Clinical and genetic correlates of a circadian subtype of depression in the Australian Genetics of Depression Study.

BACKGROUND Although commonly accepted depressive subtypes reflect phenotypic differences, there has been minimal progress in identification of discrete pathophysiological pathways, biomarkers or differential therapeutic approaches to effectively guide clinical management. AIMS To test the biological validity and clin...

E. Tonini, J. Crouse, M. Shin et al. · 1 citation
Open access Sep 2026

Sex differences in the genetic architecture of clinical quantitative traits in the electronic health record

Sex differences exist in complex diseases, but the genetic architecture of sex differences in quantitative clinical traits is understudied. Here, we performed sex-stratified genome-wide association studies of 508 clinical traits from electronic health records (EHRs) in 64,956 European-ancestry individuals in the Vander...

Freida Blostein, B. Bose, Alexander M. Hill et al. · 0 citations

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