Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression.
Phagocytic synapse enhancers are developed, a class of modular immune engagers comprising a high-affinity PD-L1 binder coupled to a macrophage-stimulating peptide, tuftsin, that provides a blueprint for a plug-and-play platform of immune engagers targeting diverse cancer-associated pathways.