Open access
Jul 2026
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
A high-throughput clustered regularly interspaced short palindromic repeats (CRISPR) prime editing platform enabling precise, reversible and combinatorial mutagenesis of canonical and noncanonical histone H3 genes within their native genomic context is developed.
Daniel Price, Grigory Zemlyanskiy, Watanya Trakarnphornsombat et al.
· Nature Genetics · 2 citations