Author

Alfredo Sanchez-Solano

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Open access Sep 2026

ORAI Ca2+ Channels and STIM1 Drive Capillary-to-Arteriole Communication in Neurovascular Coupling

Neurovascular coupling (NVC), initiated by the brain’s dense capillary network, matches blood flow to neuronal activity, yet key underlying mechanisms remain unresolved. We found that ORAI1 channels and their regulator STIM1, the main drivers of store-operated Ca2+ entry, are essential for communicating neuronal metabo...

Boris Lavanderos, Alfredo Sanchez-Solano, Wan-Chun Zhu et al. · Science Signaling · 1 citation

Open access Oct 2026

Ryanodine receptor cluster remodeling links COL4A2 mutation to cerebral artery dysfunction

Pathogenic variants of COL4A1 and COL4A2, which encode the α1 and α2 chains of type IV collagen in vascular basement membranes, cause cerebral small vessel disease and intracerebral hemorrhage, but the signaling mechanisms that precede vascular damage remain incompletely defined. Here, we investigated cerebral arterial...

Boris Lavanderos, Evan Yamasaki, Alfredo Sanchez-Solano et al. · bioRxiv · 0 citations