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Author

Alice Eddershaw

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Open access Oct 2026

Development of Organocatalytic Switches of OGG1 that Protect Mitochondria under Oxidative Stress

Mitochondrial dysfunction is a major component of neurodegeneration. The mitochondrial genome is prone to oxidative damage, and repair proteins are important to maintain mitochondrial DNA integrity. OGG1 initiates base excision repair of oxidative DNA lesions in both nuclear and mitochondrial genomes. While inhibitor...

Maeve Long, James R. Tribble, Rahul Upadhyay et al. · 0 citations
Open access Aug 2026

Structural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaP.

The 3.0 Å cryo-electron microscopy apo-structure of the PGT enzyme WbaP from Escherichia coli, a UDP-galactose:undecaprenolphosphate galactose-1-phosphoryl transferase, provides new insights into the PGT family of enzymes.

M. Weckener, Audrey Le Bas, Philip N. Ward et al. · 0 citations

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