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Author

Alice Métais

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Open access Oct 2026

Real-life efficacy and tolerance of trametinib in BRAF-rearranged low-grade gliomas: A multicenter study.

BACKGROUND MEK inhibition has demonstrated activity in pediatric low-grade gliomas (pLGGs) driven by BRAF rearrangements, but data on trametinib remain limited, regarding efficacy, short and long-term toxicities. METHODS We conducted a retrospective multicenter study of patients with BRAF-rearranged non NF1 pLGGs rec...

Céline Khouri, Amandine Bibollet, Y. Bouchoucha et al. · 0 citations
Sep 2026

[New developments in grading of astrocytomas, IDH-mutant: Study of the impact of update 12 of cIMPACT-NOW].

INTRODUCTION The 2021 World Health Organisation (WHO) classification of the Central Nervous System tumors introduced, for the first time, a molecular biomarker (homozygous deletion of CDKN2A/B) into the grading of astrocytomas, IDH-mutant. Since then, the cIMPACT-NOW expert group has proposed a new prognostic algorithm...

A. Tauziède-Espariat, Alice Métais, F. Sassi et al. · 0 citations

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