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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Alicia Kaijun Poo

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Sep 2026

Rational Engineering of the Radical SAM Enzyme HtkB Expands the Chemical Space of Cyclophane RiPPs

Cyclophane-containing peptides represent a structurally diverse class of macrocycles with important applications in drug development due to their stability and target specificity. Radical S-adenosylmethionine (rSAM) enzymes are key catalysts for cyclophane formation and execute chemically challenging C(sp2)–C(sp3) cr...

Qian-Qian Guo, Yi Jia Low, Alicia Kaijun Poo et al. · 0 citations

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