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Author

Alissa Wilhalm

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Open access Aug 2026

Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart

The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear. Here, we demonstrate that mitochondrial S-adenosylmethionine (mitoSAM) import through SLC25A26 becomes limiting shortly...

Anastasia Rumyantseva, Trevor S. Tippetts, Alissa Wilhalm et al. · 1 citation

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