Review
Open access
Sep 2026
Physical exercise and circulating α-Klotho in humans: a systematic review and meta-analysis with emphasis on older adults
Introduction Global aging and the growing burden of age-related disease have intensified interest in modifiable biomarkers of biological age. α-Klotho, the product of the KL gene, is a pleiotropic anti-aging protein whose circulating (soluble, s-Klotho) form declines with age and is independently associated with all-ca...
A. Abduldayeva, S. Iskakova, G. Doszhanova et al.
· Frontiers in Sports and Acti... · 0 citations