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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Alla V. Korepanova

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2 papers indexed here

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Open access Sep 2026

Design and Exploration of a Tricyclic Series of CNS-Penetrant CD38 Small Molecule Inhibitors

Cluster of Differentiation 38 (CD38) plays a key role in NAD+ metabolism and calcium signaling, and recent reports highlight therapeutic opportunities for CD38 modulation in central nervous system (CNS) disorders. In this report, we describe the rational design, synthesis, and exploration of structure–activity relati...

Timothy R. Hodges, Youngjin Jang, Katerina M. Korch et al. · 0 citations
Jul 2026

Discovery of Potent and Orally Bioavailable Diaminoquinazoline-Derived mRNA Decapping Scavenger (DcpS) Enzyme Inhibitors for Treatment of Solid Tumors.

Decapping Scavenger (DcpS) enzyme, a pyrophosphatase involved in mRNA regulation via mRNA cap degradation, has been identified as a promising oncology target in fragile histidine triad (FHIT) deficient cancers such as AML and GBM but remains underexplored in broader solid tumor indications. We have discovered a novel D...

S. Scholz, A. Dudnik, Aristidis Vasilopoulos et al. · 0 citations

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