Alma C. Castañeda-Leautaud

Discovery of two novel small-molecule series with potent SARS-CoV-2 inhibition via putative nsp13 open-state trapping

We report the discovery of 31 SARS-CoV-2 inhibitors identified across two computational-to-experimental screening campaigns, with average cell-based antiviral potency satisfying 〈EC50〉 ≤ CC50/3 in A549-hACE2 cells. These compounds were selected from 60 successfully tested molecules evaluated using nanoluciferase repo...