Methyl-CpG-binding domain protein 3 (MBD3) is a member of the methyl-CpG-binding domain (MBD) family, which functions as a scaffold within the nucleosome remodeling and histone deacetylase complex (NuRD). MBD3 has been studied extensively in pluripotency and gene regulation, particularly through chromatin remodeling. E...
Serine/threonine‐protein kinase 10 (STK10), an ERM protein kinase, functions as a membrane–cytoskeleton linker and regulates lymphocyte cortical rigidity, cell shape, adhesion, and migration. Despite its emerging relevance in immune regulation and cancer, the phosphoregulatory mechanisms governing STK10 remain poorly u...
Vaishnavi Gopalakrishnan, Amal Fahma, Althaf Mahin et al.· BioMed Research Internationa...· 0 citations
Lipin-1 (LPIN1) is a nucleocytoplasmic phosphatidate phosphatase and transcriptional coregulator that plays essential roles in lipid metabolism, insulin signaling, and energy homeostasis. Although LPIN1 function is extensively regulated by phosphorylation, the biological significance of individual phosphosites remains...
Bristow Ben Joseph, Pathiyil Sajini Sekhar, Athira Perunelly Gopalakrishnan et al.· Omics· 0 citations
Unc-51-like autophagy-activating kinase 1 (ULK1), a serine/threonine kinase, is the central regulator of autophagy initiation and plays a crucial role in cellular homeostasis, metabolic adaptation, and stress responses. We performed a large-scale phosphoproteomic data analysis of ULK1 by systematically integrating and...
Furqaan Ahmed Basha, Sreeshma Ravindran Kammarambath, Leona Dcunha et al.· International Journal of Mol...· 0 citations
Background: Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is a serine/threonine kinase that exhibits oncogenic activity in various cancers. Despite the established role of MAP3K3 in signal transduction, its phosphosignaling landscape, including the mechanisms underlying its activation and the identification...
