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Author

Aly A. M. Shaalan

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Open access Aug 2026

Liposomal Honokiol Nanoparticles Attenuate Manganese-Induced Hippocampal Neurotoxicity via NRF2/HO-1 and SIRT1/PGC-1α Pathways: Association with Oxidative Stress, Neuroinflammation, Mitochondrial Dysfunction, and Apoptosis

Highlights What are the main findings? Manganese exposure is associated with hippocampal oxidative stress, mitochondrial dysfunction, neuroinflammation, neurotransmitter imbalance, and apoptosis, with structural neuronal damage in rats. Liposomal honokiol nanoparticles are associated with reversal of Mn-induced alterat...

Raed AlRuwaili, E. Elmorsy, M. Abdel-Daim et al. · 0 citations
Open access Sep 2026

Liposomal Morin Attenuates DMH-Associated Colonic Oxidative Stress, Inflammation, and Apoptosis/Autophagy-Related Dysregulation in Rats

In DMH-exposed rats, MOR-Lips were associated with more favorable redox, inflammatory, proliferative, apoptosis-related, autophagy-related, and histopathological profiles than free MOR, which supports further investigation of MOR-Lips as a formulation strategy for improving the biological activity of morin.

M. Akeel, E. Elmorsy, F. Alshammari et al. · 0 citations
Open access Aug 2026

Hesperetin-Loaded PLGA Nanoparticles Ameliorate Cisplatin-Induced Oxidative Stress and Testicular Dysfunction in Rats: Association with NRF2/HO-1, NF-κB, and ACSL4/GPX4/SLC7A11 Signaling Modulation

HES and HES-PLGA-NPs were associated with multi-mechanistic protection against cisplatin-induced oxidative, inflammatory, apoptotic, and ferroptosis-associated damage in the testes, and may represent a promising nanoantioxidant candidate warranting further investigation for preserving male reproductive function during...

Mohammed A. Akeel, E. Elmorsy, Aly A. M. Shaalan et al. · 0 citations

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