Author

Aly O. Abdelkareem

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Open access Nov 2026

spOT-NMF: gene expression deconvolution via optimal transport with proximity-aware niche mapping for spatial transcriptomics

Abstract Spatial transcriptomics enables direct profiling of cellular organization within intact tissues, yet two challenges limit its full exploitation: accurate reference-free deconvolution of mixed expression signals (including species-admixed models such as xenografts), and lack of tools that can translate per-spot...

Aly O. Abdelkareem, Gurveer S. Gill, V. Manoharan et al. · Briefings in Bioinformatics · 0 citations

#artificial intelligence Preprint Oct 2026

Mem++: Non-Destructive Memory for Long-Term Organizational LLM Agents

Large Language Model (LLM) agents now take part in organizational work, where many authors record decisions across documents over months. Because a revised decision arrives as a new document rather than an edit, answering a question requires knowing which version held at a given time. However, most memory systems compr...

Ahmad Yehia, Aly O. Abdelkareem, Islam Ahmed et al. · 0 citations