New 1,3,4-oxadiazole derivatives as potential anticancer agents against esophageal cancer: Synthesis, biological evaluation, molecular docking, and density functional theory study
Four new 1,3,4-oxadiazole derivatives (L1-L4) were synthesized through a four-step synthetic pathway involving hydrazide formation, cyclization to the 1,3,4-oxadiazole ring, hydrazination, and hydrazone formation by condensation with appropriate aldehydes. Their anticancer potential against esophageal adenocarcinoma (S...