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Alzheimer’s Disease Neuroimaging Initiative

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Open access Aug 2026

Explainable Deep Learning Reveals Distributed Neurodegeneration Signatures of Neuropsychiatric Symptoms Across the Alzheimer's Continuum

Neuropsychiatric symptoms (NPS) are increasingly recognized as critical components of the disease progression in Alzheimer's disease (AD), yet their relationship with neurodegeneration remain poorly characterized. We investigated the multivariate relationships between structural MRI (sMRI)-based regional neurodegenerat...

B. Yaghooti, S. Ishrat, H. Le et al. · medRxiv · 0 citations

Open access Sep 2026

Alzheimer's Polygenic Risk Scores Are Not Interchangeable: Evidence from 1,752 Models

Introduction: Polygenic risk scores (PRS) may improve Alzheimer's disease (AD) risk prediction before symptom onset, yet choosing an appropriate model can be challenging. Methods: Using the standardized GenoPred pipeline, 1,752 PRS models (9 algorithms; 584 configurations; 3 genome-wide association studies) were evalua...

E. Ward, P. T. Nelson, Y. Katsumata et al. · medRxiv · 0 citations

Open access Sep 2026

Data-driven subtypes of Alzheimer’s Disease: A multicohort study

INTRODUCTION: Individuals with Alzheimer's disease (AD) exhibit substantial heterogeneity in the severity of vascular changes and neurodegeneration, making the identification of biologically meaningful subtypes across the AD spectrum critical for improving prognosis and tailoring interventions. We aimed to determine wh...

Amelie Metz, Cassandra Polizzi, R. Moqadam et al. · medRxiv · 0 citations