Abstract Introduction Some phthalates and their replacements are endocrine disrupting chemicals (EDCs) found in consumer products and linked to hypertensive disorders of pregnancy (HDP). Few studies have evaluated associations between EDCs and gestational blood pressure. Objective To evaluate associations between EDC biomarkers with gestational blood pressure. Methods The Environmental Reproductive and Glucose Outcomes study (N = 338) measured urinary concentrations of 18 phthalate and replacement metabolites and systolic (SBP) and diastolic (DBP) blood pressure at 3 pregnancy study visits (median: 12, 19, and 26 weeks’ gestation). Individual metabolite concentrations and summary measures based on common source or mechanism (eg, ΣPersonal care products [ΣPCP]) were log2-transformed, specific-gravity corrected, and modeled continuously and in quartiles. We estimated covariate-adjusted associations of individual metabolites and, summary measures with blood pressure using linear regression, and with HDP using log-binomial regression, assessing metabolite mixtures using Bayesian Kernel Machine Regression. Results HDP prevalence was 12.7%. Higher concentrations of monoethyl phthalate (MEP) and ΣPCP were most consistently associated with SBP and DBP elevations at visit 3. Higher concentrations of MEP (Q4 vs Q1) were associated with 4.59 mmHg higher SBP (95% CI: 0.04, 9.15), and higher ΣPCP (Q3 vs Q1) were associated with 5.78 mmHg (95% CI: 1.59, 9.97). Higher MEP and ΣPCP (Q4 vs Q1) were positively linked to DBP elevations of 4.51 to 4.70 mmHg. Other phthalate biomarkers were associated with blood pressure at specific time points. Discussion Certain urinary phthalate biomarkers, particularly MEP and ΣPCP, were associated with higher blood pressure levels in pregnancy, with implications for HDP.
K. Parra, Emma V. Preston, Marlee R. Quinn et al.· Journal of the Endocrine Soc...· 0 citations
Background: The Milwaukee Angler Study was initiated in 2017 as part of the Biomonitoring of Great Lakes Populations Program (BGLP-III) to examine two adult populations at high risk of per- and polyfluoroalkyl substances (PFAS) exposure from consumption of PFAS-contaminated sportfish: licensed anglers near the Milwaukee Estuary Area of Concern (AOC) and Burmese refugees for whom fish is a dietary staple. Objective: This study seeks to provide a comprehensive examination of serum PFAS concentrations in these groups and investigate associations with locally caught fish consumption. Methods: Licensed urban anglers and Burmese refugees were independently recruited using population-specific sampling strategies. Participants completed questionnaires on demographics and fish consumption and provided biological specimens. Median and 95th percentile concentrations of seven PFAS were compared to 2017–2018 National Health and Nutrition Examination Survey (NHANES) data. Multivariable regression assessed associations between serum PFAS concentrations and self-reported local fish consumption from the Milwaukee AOC. Results: Among the 396 licensed angler participants, serum concentrations of three of the seven PFAS (PFOS, PFHxS, PFNA) were elevated compared to the U.S. population; PFOS, PFDA, PFHxS, PFNA, and total PFAS were significantly associated with increased local fish consumption when controlling for other demographic factors. Among the 103 Burmese refugee participants, four of the seven measured PFAS (PFOS, PFDA, PFUnDA, PFNA) were elevated compared to the U.S. population; PFOA, PFOS, PFDA, and total PFAS were associated with increased local fish consumption when controlling for other demographic factors. Significance: The results from this study support an association of local fish consumption with PFAS exposure among high-risk populations with varied demographic and local fish consumption practices in the Milwaukee Estuary AOC. Given that adherence to and awareness of state fish advisories can vary widely, our biomonitoring results underscore the importance of ongoing, tailored efforts to deliver culturally relevant public health interventions to the diverse populations surrounding the Great Lakes basin. Impact Statement: Building on the Biomonitoring of Great Lakes Populations program, this study adds PFAS-focused data from Milwaukee’s urban anglers and Burmese refugees, two understudied, high-exposure groups in the Milwaukee Estuary Area of Concern. By integrating detailed fish-consumption histories with serum PFAS and NHANES comparisons, the work directly informs Great Lakes Restoration Initiative goals and targeted fish-advisory interventions. These findings offer actionable evidence for exposure scientists, environmental epidemiologists, and public health practitioners.
T. Serio, Carrie Tomasallo, Xiaofei He et al.· Journal of Exposure Science...· 0 citations
It is suggested that PFAS may be linked to inflammation and impaired fibrinolysis in midlife women, and none of these associations remained statistically significant after false discovery rate correction.
Yundan Zhang, Wenzhi Zhang, Carrie A. Karvonen-Gutierrez et al.· JACC: Advances· 0 citations
Firefighters assigned to structure defense had significantly higher increases in PAH metabolites compared to those assigned to wildland firefighting tasks and maximum post-fire concentrations in firefighters also exceeded the BEI for 1-hydroxyprene and trans,trans-muconic acid.
Miriam M Calkins, Alexander C. Mayer, Derek J Urwin et al.· International Journal of Hyg...· 0 citations