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Author

Amanda Huang

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Review Open access Sep 2026

The role of IRF5 as an immune regulator

Abstract Interferon regulatory factor 5 (IRF5) is a transcription factor at the nexus of immune regulation, inflammation, and autoimmune disease. Studies have shown that dysregulation of IRF5 is strongly implicated in the pathogenesis of autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthr...

Laura Menocal, Amanda Y. Y. Huang, Anjali Rachelkar et al. · 0 citations
Open access Aug 2026

Myeloid IRF5 is required for TLR7-driven inflammatory hemophagocyte differentiation and Macrophage Activation Syndrome

In TLR7-driven macrophage activation syndrome (MAS), inflammatory hemophagocytes (iHPCs) differentiate from Ly6CHI monocytes, phagocytose red blood cells and promote disease, including anemia and thrombocytopenia. We demonstrate here that IRF5 is required for iHPC differentiation and MAS in TLR7-overexpressing (TLR7.1)...

Natalie K. Thulin, Ai-Ling Lu, Susana L. Orozco et al. · 0 citations
Open access Jul 2026

Beyond Transcription: T cell-Intrinsic IRF5 Regulates Metabolism and Post-Transcriptional Responses in Autoimmunity 2309706

Modulating IRF5 may offer a strategy to manipulate aberrant T cell responses and mitigate T cell-mediated autoimmune conditions, and integrates TCR signaling, metabolic reprogramming, and effector function.

Betsy J. Barnes, Leianna Brune, Zarina Brune et al. · 0 citations

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