Amanda Pauli

The orientation of cholesterol’s hydroxy group affects its membrane dynamics and intracellular transport

Summary The brain, though less than 10% of body mass, contains about 25% of total cholesterol (CHL), emphasizing CHL’s key role in neuronal function. Many actions of CHL are stereospecific, as shown by differences from its 3α-hydroxy epimer, epicholesterol (epiCHL). How this minor structural change alters membrane prop...