Amani A. Hariri

Spatial decoupling of recognition and signaling in aptamer switches via tri-strand intermolecular competition

Despite decades of progress in aptamer engineering, the development of a single, modular signaling architecture capable of transducing target recognition into a measurable output across structurally diverse analytes remains an unmet challenge in biosensing. We report the Competitor Bridge Aptamer (CoBrA) framework: a m...