Open access
Aug 2026
Chromatin accessibility classification of TAD boundaries discloses new architectural proteins
Abstract 3D genome organization is crucial to modulate gene expression. Topologically associating domain boundaries isolate genes and their regulatory elements within the same topological neighborhood, avoiding crosstalk between regulatory elements. Perturbation of domain boundaries causes aberrant genomic contacts and...
Karina Jácome-López, Leonardo Ledesma-Dominguez, A. Esquivel-López et al.
· Nucleic Acids Research · 0 citations