The structural modification of morphinan alkaloids remains a vital strategy for developing therapeutics with optimized efficacy and reduced side effects. Herein, we report the rational design and synthesis of a novel library of seventeen 1,4-disubstituted 1,2,3-triazole-tethered codeine derivatives (13a-13q). Utilizing...
Saman Gharehnaghadeh, Peyman Salehi, Morteza Bararjanian et al.· RSC Medicinal Chemistry· 0 citations
Wound healing is a complex process, the disruption of which can lead to infection, scarring, and chronic wounds. Natural agents such as naringenin, a flavonoid with antioxidant activity, and collagen, a structural protein with anti-inflammatory properties, can enhance wound repair. Niosomes are vesicular carriers that...
Amir Baghaei, Faeze Khalaj, P. Ebrahimnejad et al.· Nanomedicine: Nanotechnology...· 0 citations
The baclofen- and frankincense oil-loaded bigel demonstrated favorable physicochemical properties, good stability, enhanced skin permeation, and the greatest analgesic effect among the tested formulations, suggesting its potential as an effective topical delivery system.
Amir Baghaei, Soada Asadi, M. Ahmadian-Attari et al.· Journal of Pharmaceutical In...· 0 citations
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