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Author

Amir Khan

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Open access Aug 2026

Spatial remodeling of the thymic stroma with age disrupts niches for T cell selection and tolerance

A spatially resolved multi-omic atlas of the aging mouse thymus is generated and reframe thymic involution as spatial stromal reorganization that links stromal remodeling to impaired thymopoiesis, central tolerance, and immune aging.

Andreas Tarcevski, Fatima Dhalla, Joshua W. Moore et al. · 0 citations
Open access Jul 2026

Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner

It is shown that disruption of chromatin organization by degron-mediated CTCF and/or WAPL depletion promotes totipotent-like conversion through the DPPA2/DUX axis, accompanied by changes in chromatin accessibility and nucleolar integrity.

Grace Carey, Maria Vega-Sendino, Desiree Tillo et al. · 2 citations

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