Author

Amir Zarrinpar

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Oct 2026

Tn7 Integration Efficiently Introduces Gene Expression Cassettes into a Gut-Native Escherichia coli Strain

Native bacteria are strains isolated from the host and often require greater development and optimization of genetic manipulation tools than lab-adapted strains. We have previously shown that the native murine Escherichia coli strain EcAZ-1, which colonizes the conventional mouse gut long term, is genetically tractab...

David M. Zong, Sharyl Bailey, Zainab Fatima et al. · ACS Synthetic Biology · 0 citations

Open access Sep 2026

Gut microbiome and metabolite profiles are associated with subsequent histologic MASH in a longitudinal mouse model

ABSTRACT Detecting metabolic dysfunction-associated steatohepatitis (MASH) before fibrosis develops remains a major challenge. We used a longitudinal streptozotocin/high-fat diet (STAM/HFD) mouse model to identify microbial and metabolic features that emerge before histological MASH onset. Integrative 16S rRNA and unta...

Stephany Flores Ramos, Kelly A. Fogelson, V. Muti et al. · mSystems · 0 citations

Review Jul 2026

Engineering commensal microbes for host health.

This review summarized recent progress in the development of eLBPs across diverse disease indications, including inflammatory diseases, metabolic disorders, cancer, and infectious diseases, and proposed framework for the rational design of next-generation eLBPs that can more reliably translate from experimental systems...

Elizabeth A. Brown, Arianna Brevi, David Zong et al. · Cell Host and Microbe · 0 citations