Amit Kumawat

SCRIB inhibits PP1 phosphatase activity without blocking or structurally altering its active site.

Protein phosphorylation is a fundamental mechanism regulating cellular function, governed by the opposing actions of kinases and phosphatases. The substrate specificity and catalytic activity of protein phosphatase 1 (PP1), a major serine/threonine phosphatase, results from its interactions with more than 200 regulator...