Early-Onset Colorectal Cancer: Epidemiology, Etiologic Pathways, and Emerging Prevention Strategies.
Early-onset colorectal cancer (EOCRC), defined as CRC diagnosed before age 50, is rising globally despite declining incidence in older adults, representing a growing public health concern. This review synthesizes current evidence on EOCRC epidemiology, molecular features, etiologic hypotheses, and clinical implications...