Author

Amit V. Pandey

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Open access Oct 2026

Discovery and Characterization of Novel Piperidine Derivatives as Potent Cytochrome P450 17A1 Inhibitors for Prostate Cancer Therapy.

Castration-resistant prostate cancer relies on intratumoral androgen synthesis mediated by cytochrome P450 17A1 (CYP17A1). Treatment with the only clinically used CYP17A1 inhibitor, abiraterone, is limited by resistance and side effects, underscoring the urgent need for new CYP17A1 inhibitors with greater selectivity a...

Angelika Grudzińska, J. Yakubu, C. Vigato et al. · ChemMedChem · 0 citations

Open access Aug 2026

RC12.3 - LBA_ECE_1400 - Profiling of CYP17A1 mutations defines the molecular basis of partial enzyme deficiencies

17α-hydroxylase/17,20-lyase deficiency (17-OHD) is a rare form of congenital adrenal hyperplasia characterized by hypertension, hypokalemia, and sexual infantilism. Its spectrum ranges from complete deficiency to partial forms with spontaneous puberty and fertility, yet the molecular basis of this heterogeneity r...

Kai-Ge Li, J. Yakubu, Amit V. Pandey · European Journal of Endocrin... · 0 citations