Author

Amna Tamimi

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Review Jul 2026

EGFR Dysregulation in Cancer: From Molecular Mechanisms and Key Mutations to Evolving TKI Strategies and Resistance Mitigation.

This review provides a comprehensive overview of EGFR biology, its signaling pathways, and strategies for therapeutic targeting and explores fourth-generation TKIs and allosteric inhibitors alongside newer treatment strategies, such as PROTACs, combination immunotherapy, and precision medicine methods.

Amna Tamimi, Mantasha Khan, M. K. A. Khan et al. · Current Medicinal Chemistry · 0 citations