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Author

Amr Sonousi

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Open access Sep 2026

Synthesis, in vitro and in silico evaluation of quinazoline and triazoloquinazoline derivatives as PDE7A inhibitors

Background and purpose: Phosphodiesterase 7A (PDE7A) is an attractive therapeutic target for the treatment of inflammatory, autoimmune, and neurodegenerative disorders through modulation of intracellular cAMP levels. However, the development of highly potent and selective PDE7A inhibitors remains challenging. This stud...

Afaf A. El-Malah, M. M. Gineinah, M. Khayat et al. · 0 citations
Aug 2026

Design, Synthesis, and Antibacterial Evaluation of Novel Non‐Oxazolidinone Analogues of Linezolid to Investigate the Role of the Oxazolidinone Ring

A new series of non‐oxazolidinone derivatives designed and synthesized as potential analogues of Linezolid exhibited lower antibacterial activity compared to Linezolid and gentamycin, highlighting the crucial role of the oxazolidinone ring in its antibacterial activity.

M. T. M. Nemr, Laila Ziko, Lobna Ghonaim et al. · 0 citations

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