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Sep 2026

Prevalent and characteristic alterations in blood-brain transcriptomic-functional imaging coupling in schizophrenia.

Findings reveal distinct, reproducible dysregulation of peripheral-central functional coupling in SCZ, offering a multi-scale framework for understanding its pathophysiology and highlighting the potential of trans-scale features as candidate biomarkers for diagnosis and mechanistic insight.

Yu-Sha Ji, Yi-Feng Liu, Zhi-Qiang Mu et al. · 0 citations
Open access Sep 2026

CRISPRa-identified transcription factors reprogram glioblastoma into dendritic cell-like cells to elicit systemic antitumor immunity

A candidate-based CRISPR activation (CRISPRa) functional screen is developed to identify regulators of conventional dendritic cell (cDC)-fate specification and concludes that the transcription factors Zfp366/Znf366, Pu.1, Irf8, and Batf3 (ZPIB) are sufficient to convert GBM cells into cDC-like cells.

Xiao Liu, Mao-Rong Zhu, Cheng Zou et al. · 0 citations

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