A recombinant pseudorabies virus co-expressing G2b and G2c S1 broadens neutralizing antibody responses against PEDV variants and enhances pre-existing vaccine-induced antibody responses.
Porcine epidemic diarrhea virus (PEDV) G2c variants harbor substantial antigenic alterations that reduce the cross-neutralizing activity of antibodies induced by current vaccines and may contribute to vaccine failure in the field. To explore a vaccine candidate capable of broadening antibody responses against genetical...