An-Li Zhang

Design, synthesis, and biological evaluation of novel dual-functional NMT/IDO-1 inhibitors with fungicidal and immunomodulatory activities.

Invasive fungal infections, particularly those caused by fluconazole- resistant strains, remain a major clinical challenge owing to the limited therapeutic options currently available and the immunosuppressive state induced by the infection. Herein, we report the rational design of a series of dual-targeting small mole...