An-Ping Ma

Multi-omics analysis reveals oxidative stress-associated alterations in glycerophospholipid metabolism and inflammatory response in 6PPDQ-exposed macrophages.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ), a transformation product of the tire antioxidant 6PPD, is an emerging environmental contaminant with increasing toxicological concern. While macrophages are critical in recognizing and managing chemical stress, how 6PPDQ exposure perturbs their innate...