An-Xin Wang

Structure Basis for Chloride Recognition and Transport by Human Kidney Brain Anion Transporter (KBAT)

SLC26A11, also known as the kidney and brain anion transporter (KBAT), mediates the transport of multiple anionic substrates across the plasma membrane. It is highly enriched in cerebellar Purkinje cells, where loss of KBAT results in hyperpolarized membrane potentials and increased intrinsic firing frequency, correlat...