Uridine phosphorylase 1 (UPP1) has recently emerged as a metabolic regulator with critical roles in tumor cell biology. However, its expression pattern and functional significance in nonmalignant components of the tumor microenvironment (TME) remain largely unexplored. Here, we performed a comprehensive pan-cancer sing...
Immune memory has long been attributed to adaptive immunity, but trained immunity has broadened this view by showing that innate immune cells can retain altered function after prior stimulation and mount an enhanced response upon rechallenge. In the lung, prior local exposures can alter resident alveolar macrophages, w...
Xin-Yu Sun, Dan Zhao, Lei Zhang et al.· Frontiers in Immunology· 0 citations
This review systematically dissects the molecular underpinnings of OV‑triggered immunogenic cell death—encompassing apoptosis, necroptosis, and autophagy—as well as their distinct and overlapping contributions to antitumor immunity.
Ji-Liu Liu, Rui-Tong Zeng, Guo-Ping Li et al.· Translational Lung Cancer Re...· 0 citations
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