Author

Ana Conesa

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Open access Sep 2026

Handling biological replicates in long-read RNA sequencing data by joining or not joining

While isoform identification from long-read RNA sequencing (lrRNA-seq) data has received significant attention, the handling of biologically replicated lrRNA-seq datasets remains less explored. This study defines two strategies for obtaining consensus transcriptomes from multi-sample lrRNA-seq data: Join & Call, where...

Fabian Jetzinger, Alejandro Paniagua, Stanley Cormack et al. · Nature Communications · 1 citation

Review Open access Oct 2026

Deciphering transcriptome complexity via long‐read sequencing

Abstract Transcriptomics is moving beyond gene‐level quantification toward isoform‐resolved interrogation of alternative splicing, transcript structural variation, and repeat‐derived transcription. Yet short‐read sequencing remains intrinsically limited in accurately reconstructing full‐length transcripts and resolving...

Chu-Wen Xu, Jia Li, Chen-Xi Yin et al. · iMeta · 0 citations

Open access Aug 2026

Integrative microbiome–methylome analysis links bacterial taxa to colorectal cancer histological subtypes

ABSTRACT Colorectal cancer (CRC) arises through distinct molecular and histological routes that may be shaped by interactions between the mucosa-associated microbiota and host epigenetic regulation. We analyzed paired tumor and adjacent non-tumor colorectal mucosa from CRC patients stratified by histological subtype (c...

Á. Escudero-Jiménez, J. Galán-Ros, Francisco Huertas-López et al. · mSystems · 0 citations