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Ana L. Marçal

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Review Open access Sep 2026

Nitric oxide as a mechanistic link between metabolic dysfunction and cognitive decline in type 2 diabetes

Abstract Type 2 diabetes mellitus (T2DM) is increasingly recognised as a driver of cerebrovascular dysfunction and cognitive decline, yet the molecular mechanisms underlying this association remain incompletely understood. Here, we review and support a key mechanistic role for nitric oxide (•NO), a pleiotropic diffusib...

Ana L. Marçal, João Laranjinha, C. Lourenço · 0 citations

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