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Author

Anand T. Vaidya

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Open access Jul 2026

Conformation of the Catalytic Lysine is a Key Determinant of 2-Deoxyribose-5-phosphate Aldolase (DERA) Stereoselectivity

2-Deoxyribose-5-Phosphate Aldolase (DERA) is a key enzyme in the pentose phosphate pathway. Due to its C-C bond formation and stereoselective capabilities, DERA has been widely used for biocatalytic applications including the synthesis of chiral intermediates for antiviral and anticancer drugs. While protein engineerin...

S. Dutta, Ananya Nayak, Jeevani Kodru et al. · 0 citations
Open access Jul 2026

Integrative structure determination of a human mitochondrial contact site and cristae organizing system (MICOS) sub-assembly

The results indicate that Mic13 likely facilitates MICOS assembly by binding Mic10 in the IMM-proximal region and Mic60 in the intermembrane space, and several likely-pathogenic missense mutations also localize to these novel interfaces, highlighting their importance.

Muskaan Jindal, Rakesh Mahato, Sreemoyee Das et al. · 0 citations

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