Biological Investigation of Novel Pyrazole-Based Anticancer Scaffolds: A Trinity of Synthetic Methodologies on Computational Assessment of IC50 Against Human Cancer Cell Lines MCF-7, MDA-MB and HeLa.
Aurora kinase A (AURKA) is a key regulator of mitotic progression and is frequently overexpressed in human malignancies, making it an attractive therapeutic target for the development of targeted anticancer agents. The present study aimed to design and synthesize sixteen novel pyrazole derivatives (Pz-01 to Pz-16) as p...